Gaurav Kumar Sharma : Eight cups of water a day by Gaurav Kumar Sharma

Gaurav Kumar Sharma : Eight cups of water a day by Gaurav Kumar Sharma: Do you really need to drink eight cups of water a day? Drinking eight cups or two litres of water a day is longstanding advice. But is...

Eight cups of water a day by Gaurav Kumar Sharma

Do you really need to drink eight cups of water a day?

Drinking eight cups or two litres of water a day is longstanding advice. But is there any scientific basis for it, asks 

Dr Chris van Tulleken.

You know those ads that remind us that even a small drop in hydration levels can massively affect performance so you need to keep hydrated with whatever brand of isotonic super drink they're selling?

They seem pretty scientific don't they? Man in white coat, athlete with electrodes attached and so on. And it's not a hard sell because drinking feels right - you're hot and sweating so surely replacing that fluid must be beneficial.

Well earlier this year sports scientists in Australia did an extraordinary experiment that had never been done before (British Journal of Sports Medicine, September 2013, Current hydration guidelines are erroneous: dehydration does not impair exercise performance in the heat, Wall BA).

This group wanted to find out what happened to performance after dehydration. So they took a group of cyclists and exercised them until they lost 3% of their total body weight in sweat.

Then their performance was assessed after re-hydration with either 1) nothing, 2) enough water to bring them back to 2% dehydration or 3) after full re-hydration.

So far nothing unusual, but the difference between this and almost every other study that's ever been done on hydration was that the cyclists were blind to how much water they got. The fluid was given intravenously without them knowing the volume.

This is vital because we all, and especially athletes, have such an intimate psychological relationship with water consumption.

Remarkably, there was no performance difference between those that were fully re-hydrated and those that got nothing. This study was part of a growing movement to "drink to thirst" which hopes to persuade athletes not to over hydrate with the potentially fatal consequence of diluting your sodium level, causing hyponatraemia.

Perhaps the result shouldn't be so surprising. Humans evolved doing intense exercise in extreme heat and dryness. We are able to tolerate losses in water relatively well whereas even slight over hydration can be far more dangerous. In simple terms, being too watery is as bad for you as being too concentrated.

But what about the rest of us who aren't cycling around the desert in Western Australia?

There is a very well accepted idea that we should drink about eight cups of water per day (two to three litres) in addition to our food and other drinks.

We are awash with positive messages about the healing properties of water and how it will improve everything from our brains to our bowels. And we know that without it we will die in days.

It's a short leap of logic to think that if a lack of water is bad for for you then hydration must be good - purifying, cleansing water washing through your organs must be beneficial, detoxifying. It surely improves your skin, helps you think, reduces your risk of kidney stones and turns your urine a lovely light, straw/champagne colour rather than the fetid orange syrup you produce at the end of a long day where you haven't had time to drink.

So I've looked through the literature and I found a review article saying all of this and more. It was written by a group of respected physicians from American and French hospitals and it clearly supported the widely held belief that you should drink two to three liters of water a day.

It said that people with a high urine output have a lower rate of kidney stone disease, that the flushing action of the water may reduce the risk of a urinary tract infection (especially in women after sex). Perhaps most importantly, they referenced a surprising study which showed that paradoxically an increased intake of water increased the risk of bladder cancer. But only tap water. And there's the clue.

A footnote at the end of the article explained that what you thought was a scientific article in a scientific journal is in fact a supplement, sponsored by a major mineral water manufacturer. All of the authors received honoraria from this company, which also provided medical writing assistance. So this isn't research, it's marketing.

And this is one of the reasons we're even discussing this - because increasingly drinking water doesn't just come out of our taps for free. It's sold to us by the same clever people that sell us yoghurts with bacteria in them that probably don't do us much good, something I look at separately in the television series I've been making. And these companies pretty consistently recommend two to three litres of water per day.

So where did that number come from and is there any reason to think it correct?

Well the grain of truth is this - people in temperate climates who are not doing sustained physical exercise do need around six to eight cups per day but that can be contained in food, alcohol or caffeinated beverages.

Yes, beer and coffee do not dehydrate you to any noticeable extent (there's a nice paper where some medical students got to drink quite a lot of beer and had their urine studied - British Medical Journal (Clin Res Ed), December 1982, Acute biochemical responses to moderate beer drinking, Gill GV).

There is no evidence that adding the eight cups of water to everything else you drink will do you any good and it could do you harm (American Journal of Physiological - Regulatory, Integrative and Comparative Physiology, November 2002, Drink at least eight glasses of water a day. Really? Is there scientific evidence for "8x8"? Valtin H).

But the great thing is that just like a top-level athlete you don't need to worry about exactly what that total daily requirement is because your body will sort it all out for you.

If you drink too much you pee it out. If you drink too little you get thirsty and pee less. It's all exquisitely well-controlled in the same way that your intake of oxygen is well-controlled.

Saying that you should drink more water than your body asks for is like saying that you should consciously breathe more often than you feel like because if a little oxygen is good for you then more must be better.

Like most things in life there's a Goldilocks amount - not too little and not too much. With this in mind, next week I'll deal with the health benefits of porridge and how to avoid being eaten by bears.

The Magazine on water

For most people a drink of water is a clear, tasteless liquid that quenches the thirst but Faustino Munoz can distinguish between dozens of different sorts of water, a hobby that started as a child, while helping his mother cook.

There are many things that divide the north and the south of Britain - politics, the weather - but water is probably the oddest, says Kathryn Westcott.

We are regularly advised to drink more water: it clears skin, reduces tiredness and aids concentration, but could drinking too much water be dangerous ?

Gaurav Kumar Sharma : HISTORY OF PHARMACY IN INDIA BY GAURAV KUMAR SHARM...

Gaurav Kumar Sharma : HISTORY OF PHARMACY IN INDIA BY GAURAV KUMAR SHARM...: HISTORY OF PHARMACY IN INDIA In ancient India the sources of drugs were of vegetable, animal and mineral origin. They were prepared em...

HISTORY OF PHARMACY IN INDIA BY GAURAV KUMAR SHARMA

HISTORY OF PHARMACY IN INDIA

In ancient India the sources of drugs were of vegetable, animal and mineral origin. They were prepared empirically by few experienced persons. Knowledge of that medical system was usually kept secret within a family.There were no scientific methods of standardization of drugs.

The Indian system of medicine declined during the Muslim rule while the Arabic or the Unani-Tibbi system flourished.

British rule in India

The western or the so-called Allopathic system came into India with the British traders who later become the rulers. Under British rule this system got state patronage. At that time it was meant for the ruling race only. Later it descended to the people and become popular by the close of 19th Century.

Before 1940

Initially all the drugs were imported from Europe. Later some drugs of this system began to be manufactured in this country.

1901:   Establishment of the Bengal Chemical and Pharmaceutical Works, Calcutta by Acharya P.C. Ray.

1903:   A small factory at Parel (Bombay) by Prof. T.K. Gujjar.

1907:   Alembic Chemical Works at Baroda by Prof. T.K. Gujjar.

Drugs were mostly exported in crude form and imported in finished form. During World War-I (1914 – 1920) the imports of drugs were cut-off. Imports of drugs were resumed after the War.  In absence of any restrictions on quality of drugs imoported, manufacturer abroad took advantage of the situation. The consequences were as follows:

(i) Foreign manufacturers dumped inferior quality medicines and adulterated drugs.

(ii) Markets were full of all sorts of useless and deleterious drugs were sold by unqualified men.

Examples of maladies:

· Poisoning due to quinine.

· Putting of croton oil into eye instead of atropine solution.

· Selling of chalk powder tablets in place of quinine.

· Drug santonin was badly adulterated.

· Potent drugs like compounds of antimony and arsenic and preparations of digitalis were dispensed without any standard.

Few laws were there having indirect bearing on drugs, but were insufficient.

1878	Opium Act	Dealt with cultivation of poppy and the manufacture, transport, export, import and sale of opium.
1889	Indian Merchandise Act	Misbranding of goods in general
1894	Indian Tariff Act	Levy of customs duty on goods including foods, drinks, drugs, chemicals and medicines imported into India or exported there from.
1898	Sea Customs Act	Goods with ‘false trade description’ were prevented from importing under this act.
1919	Poisons Act	Regulated the import, possession and sale of poisons.
	IndianPenal Code	Some sections of IPC have mention of intentional adulterations as punishable offence.

Some state-level law had indirect references to drugs:

1884	Bengal Municipal Act
1901	City of Bombay District Municipal Act	Concerned with food.
1909	Bengal Excise Act
1911	Punjab Municipal Act
1912	United Provinces (now Uttar Pradesh) Prevention of Adulteration Act	Refers to adulteration of foods and drugs.
1914	Pujab Excise Act
1916	United Provinces Municipalities Act	Inspection of shops and seizure of adulterated substances.
1919	Bengal Food Adulteration Act
1919	Bihar and Orissa Prevention of Adulteration Act
1919	Madras Prevention of Adulteration Act	Chiefly concerned with food adulteration
1922	Bihar and Orissa Municipal Act
1922	Central Provinces Municipalities Act
1925	Bombay Prevention of Adulteration Act
1929	Punjab Pure Food Act

The laws were too superficial and had indirect link to drugs.

Drug enquiry committee

Government of India on 11^th August 1930 , appointed a committee under the chairmanship of Late Col. R.N.Chopra to see into the problems of Pharmacy in India and recommend the measures to be taken. This committee published its report in 1931. It was reported that there was no recognized specialized profession of Pharmacy. A set of people known as compounders were filling the gap.

            Just after the publication of the report Prof. M.L.Schroff (Prof. Mahadeva Lal Schroff) initiated pharmaceutical education at the university level in the Banaras Hindu University.

In 1935 United Province Pharmaceutical Association was established which later converted into Indian Pharmaceutical Association.

            The Indian Journal of Pharmacy was started by Prof. M.L. Schroff in 1939. All India Pharmaceutical Congress Association was established in 1940. The Pharmaceutical Conference held its sessions at different places to publicize Pharmacy as a whole.

1937:   Government of India brought ‘Import of Drugs Bill’; later it was withdrawn.

1940:   Govt. brought ‘Drugs Bill’to regulate the imort, manufacture, sale and distribution of

drugs in British India. This Bill was finally adopted as ‘Drugs Act of 1940’.

1941:   The first Drugs Technical Advisory Board (D.T.A.B.) under this act was constituted.

            Central Drugs Laboratory was established in Calcutta

1945:   ‘Drugs Rule under the Drugs Act of 1940’ was established.

The Drugs Act has been modified from time to time and at present the provisions of the Act cover Cosmetics and Ayurvedic, Unani and Homeopathic medicines in some respects.

1945: Govt. brought the Pharmacy Bill to standardize the Pharmacy Education in India

1946: The Indian Pharmacopoeial List was published under the chairmanship of late Col.R.N. Chopra. It contains lists of drugs in use in India at that time which were not included in British Pharmacopoeia.

1948: Pharmacy Act 1948 published.

1948: Indian Pharmacopoeial Committee was constituted under the chairmanship of late Dr. B.N. Ghosh.

1949: Pharmacy Council of India (P.C.I.) was established under Pharmacy Act 1948.

1954: Education Regulation have come in force in some states but other states lagged behind.

1954: Drugs and Magic Remedies (Objectionable Advertisements) Act 1954 was passed to stop misleading advertisements (e.g. Cure all pills)

1955: Medicinal and Toilet Prepartions (Excise Duties) Act 1955 was introduced to enforce uniform duty for all states for alcohol products.

1955: First Edition of Indian Pharmacopoeia was published.

1985: Narcotic and Psychotropic Substances Act has been enacted to protect society from the dangers of addictive drugs.

Govt. of India controls the price of drugs in India by Drugs Price Order changed from time to time.

CODE OF ETHICS AS DRAFTED BY PHARMACY COUNCIL OF INDIA (P.C.I.)

Ethics is defined as ‘code of moral principles’. It emphasizes on the determination of right or wrong while doing one’s duty.

            Code of Pharmaceutical Ethics as formulated by Pharmacy Council of India which are meant to guide the pharmacist as to how he should conduct himself (or herself), in relation to himself (or herself), his / her patrons (owner of the pharmacy), general public, co-professionals etc. and patients.

Introduction:

Profession of Pharmacy is a noble profession as it is indirectly healing the persons to get well with the help of medical practitioners and other co-professionals. Government has restricted the practice of Pharmacy to only Profession Pharmacists i.e registered Pharmacist under the Pharmacy Act 1948. PCI framed the following ethics for Indian Pharmacists, which may be categorised under the following headings:

1.      Pharmacist in relation to his job.

2.      Pharmacist in relation to his trade.

3.      Pharmacist in relation to medical profession.

4.      Pharmacist in relation to his profession.

Pharmacist in relation to his job

A pharmacist should keep the following things in relation to his job.

(i) Pharmaceutical services

Pharmacy premises (medicine shops) should b e registered. Emergency medicines and common medicines should be supplied to the patients without any delay.

(ii) Conduct of the Pharmacy

Error of accidental contamination in the preparation, dispensing and supply of medicines should be checked in a pharmacy.

(iii) Handling of Prescription

A pharmacist should receive a prescription without any comment on it that may cause anxiety to the patient. No part of the prescription should be changed without the consent of the prescriber. In case of changing the prescription should be referred back to the prescriber.

(iv) Handling of drugs

A prescription should always be dispensed correctly and carefully with standard quality drug or excipients. Drugs that have abusive potential should not be supplied to any one.

(v) Apprentice Pharmacist

Experienced pharmacists should provide all the facilities for practical training of the apprentice pharmacists. Until and unless the apprentice proves himself or herself certificate should not be granted to him / her.

Pharmacist in relation to his trade

Following are the provisions which pharmacist should keep in mind while dealing with his trade:

(i) Price structure

The prices charged should be fair keeping with the quality, quantity and labour or skill required.

(ii) Fair trade practice

Fair practice should be adopted by a pharmacist in the trade without any attempt to capture other pharmacist’s business.

If a customer brings a prescription (by mistake) which should be genuinely by some other pharmacy the pharmacist should refuse to accept the prescription.

Imitation of copying of the labels, trade marks and other signs or symbols of other pharmacy should not be done.

(iii) Purchase of drugs

Pharmacists should buy drugs from genuine and reputable sources.

(iv) Advertising and Displays

The sale of medicines or medical appliances or display of materials in undignified style on the premises, in the press or elsewhere are prohibited.

Pharmacist in relation to medical profession

Following are the code of ethics of a pharmacist in relation to medical profession:

(i) Limitation of professional activity

The professional activity of the medical practitioner as well as the pharmacists should be confined to their own field only.

Medical practitioners should not possess drugs stores and pharmacists should not diagnose diseases and prescribe remedies.

A pharmacist may, however, can deliver first aid to the victim incase of accident or emergency.

(ii) Cladenstine arrangement

A pharmacist should not enter into a secret arrangement or contract with a physician by offering him any commission or any advantages.

(iii) Liasion with public.

A pharmacist should always maintain proper link between physicians and people. He should advise the physicians on pharmaceutical matters and should educate the people regarding heath and hygiene. The pharmacist should be keep himself / herself up-to-date with pharmaceutical knowledge from various journals or publications.

Any information acquired by a pharmacist during his professional activities should not be disclosed to any third party until and unless required to do so by law.

Pharmacist in relation to his profession

Regarding to the profession the following code of ethics should be fulfilled.

(i) Professional vigilance

A pharmacist must abide by the pharmaceutical laws and he/she should see that other pharmacists are abiding it.

(ii) Law-abiding citizens

The pharmacists should have a fair knowledge of the laws of the country pertaining to food, drug, pharmacy, health, sanitation etc.

(iii) Relationship with Professional Organizations

A pharmacist should be actively involved in professional organization, should advance the cause of such organizations.

(iv) Decorum and Propriety

A phrmacist should not indulge in doing anything that goes against the decorum and propriety of Pharmacy Profession.

(v) Pharmacists Oath

A young prospective pharmacist should feel no hesitation in assuming the following pharmacist’s oath:

·         “I promise to do all I can to protect and improve the physical and moral well-being of society, holding the health and safety of my community above other considerations. I shall uphold the laws and standards governing my profession, avoiding all forms of misinterpretation, and I shall safeguard the distribution of medical and potent substances.

·         Knowledge gained about patients, I shall hold in confidence and never divulge unless compelled to do so by law.

·         I shall strive to perfect and enlarge my knowledge to contribute to the advancements of pharmacy and the public health.

·         I furthermore promise to maintain my honour in all transactions and by my conduct never bring discredit to myself or to my profession nor to do anything to diminish the trust reposed in my professional brethren.

·         May I prosper and live long in favour as I keep and hold to this, my Oath, but if violated these sacred promises, may the reverse be my lot.”

SCOPE AND POTENTIAL OF PHARMACY

D. PHARM

Business Drug Store Whole sale Repacking Bulk drug distribution Cosmetic manufacturing Service Hospital Pharmacy Chemist in Drug Store Whole sale store

 Medical representative

Packaging, store maintenance in Pharmaceutical Industry

Secretary / PA to MD in Pharm. industry

B.PHARM., M. PHARM. & PhD

Business Pharmaceutical industry Bulk Drug Manufacturing   Pharmacist job abraod Cultivation of plants(medicinal)   Public testing laboratories Consultancy Service

FDA job

Teacher for Diploma & Graduate level courses

Production

Marketing

Research and development

Gaurav Kumar Sharma : How to be Professional? by Gaurav Kumar Sharma

Gaurav Kumar Sharma : How to be Professional? by Gaurav Kumar Sharma: How to be Professional?  by Gaurav Kumar Sharma Things to know about the Professionalism 1.Don’t distrust on boss' decisi...

How to be Professional? by Gaurav Kumar Sharma

How to be Professional? 

by

Gaurav Kumar Sharma

Things to know about the Professionalism

1.Don’t distrust on boss' decisions 

At times, you may want to raise questions on his judgement. Do yourself a favour - give it a pass. You may not know what business pressures he/she is living through.

2.Don’t poke around on boss's life

Every employee wants to check what his or her boss is doing in social life. Don't blow your cover by admitting to doing it unashamed.

3.Be modest for office gossips

Never share office hearsay with your boss without checking its truthfulness. Sharing something random that you heard in the cafeteria and reacting to it may get him or her thinking that you are not mature or trustworthy.

4.Deal with your own secrets

Your life and its constant struggles are for you to handle. Pouring it all out in front of your boss will put you in a susceptible position.

5.Don’t express your expectations from the boss

The boss is mandated to put forward his/her expectations from you. But it does not mean you to go and tell the boss how you appraise his/her skill sets.